Drug interactions
Ertugliflozin + Metformin-repaglinide
Severity: Moderate
Ertugliflozin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers glucose through increased urinary glucose excretion and adds to the effect of repaglinide and metformin. The combination increases the risk of hypoglycemia, primarily from the insulin secretagogue.
What this interaction means in plain words
Ertugliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2 inhibition and insulin secretagogue action.
What to do
Monitor blood glucose and consider a lower repaglinide dose when ertugliflozin is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Ertugliflozin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers glucose through increased urinary glucose excretion and adds to the effect of repaglinide and metformin. The combination increases the risk of hypoglycemia, primarily from the insulin secretagogue.
How serious is the interaction between Ertugliflozin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider a lower repaglinide dose when ertugliflozin is started.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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