Drug interactions
Ertugliflozin + Repaglinide
Severity: Moderate
Ertugliflozin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin combined with an insulin secretagogue such as repaglinide increases the risk of hypoglycemia.
What this interaction means in plain words
Ertugliflozin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition and stimulated insulin secretion.
What to do
Consider a lower repaglinide dose when starting ertugliflozin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Repaglinide?
MediHelp rates the interaction as moderate. Ertugliflozin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin combined with an insulin secretagogue such as repaglinide increases the risk of hypoglycemia.
How serious is the interaction between Ertugliflozin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower repaglinide dose when starting ertugliflozin and monitor blood glucose.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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