Drug interactions
Ertugliflozin-sitagliptin + Ifosfamide
Severity: Moderate
Ertugliflozin-sitagliptin and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide can cause nephrotoxicity, including proximal tubular injury. Renal impairment reduces the glycemic efficacy of ertugliflozin and requires sitagliptin dose adjustment, and volume depletion with SGLT2 inhibitors may worsen kidney injury.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Ifosfamide belongs to Oncology.
Why it happens
Ifosfamide-induced renal tubular toxicity combined with SGLT2 inhibitor-related volume depletion and dependence of sitagliptin on renal elimination.
What to do
Monitor renal function, hydration status and glucose during ifosfamide therapy. Hold ertugliflozin during dehydration and adjust sitagliptin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Ifosfamide
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- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Ifosfamide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide can cause nephrotoxicity, including proximal tubular injury. Renal impairment reduces the glycemic efficacy of ertugliflozin and requires sitagliptin dose adjustment, and volume depletion with SGLT2 inhibitors may worsen kidney injury.
How serious is the interaction between Ertugliflozin-sitagliptin and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration status and glucose during ifosfamide therapy. Hold ertugliflozin during dehydration and adjust sitagliptin if renal function declines.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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