Drug interactions
Ertugliflozin-sitagliptin + Insulin degludec
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin and sitagliptin to basal insulin lowers blood glucose further and raises the risk of hypoglycemia. The risk is greatest when insulin doses are not reduced at the start of the combination.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Additive glucose-lowering effects through different mechanisms: insulin-mediated glucose uptake, SGLT2-mediated urinary glucose loss and DPP-4 inhibition enhancing incretin activity.
What to do
Consider lowering the insulin degludec dose when starting the combination and monitor blood glucose closely. Educate the patient on recognising hypoglycemia and adjust insulin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Insulin degludec
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin degludec?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin and sitagliptin to basal insulin lowers blood glucose further and raises the risk of hypoglycemia. The risk is greatest when insulin doses are not reduced at the start of the combination.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin degludec dose when starting the combination and monitor blood glucose closely. Educate the patient on recognising hypoglycemia and adjust insulin as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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