Drug interactions
Ertugliflozin-sitagliptin + Insulin glulisine
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using the ertugliflozin and sitagliptin combination with mealtime insulin glulisine increases glucose-lowering effect and the risk of hypoglycemia. Prandial insulin doses frequently need to be lowered.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Additive glucose-lowering effects via insulin action, SGLT2-mediated glycosuria and DPP-4 inhibition enhancing incretin activity.
What to do
Consider reducing the insulin glulisine dose when starting the combination and monitor blood glucose before and after meals. Adjust the dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin glulisine?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using the ertugliflozin and sitagliptin combination with mealtime insulin glulisine increases glucose-lowering effect and the risk of hypoglycemia. Prandial insulin doses frequently need to be lowered.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin glulisine dose when starting the combination and monitor blood glucose before and after meals. Adjust the dose according to readings.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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