Drug interactions
Ertugliflozin-sitagliptin + Mecasermin
Severity: Moderate
Ertugliflozin-sitagliptin and Mecasermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin (recombinant IGF-1) has insulin-like effects and can cause hypoglycemia, which may be worsened by antidiabetic drugs. The risk is higher if meals are missed.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
Additive glucose lowering because IGF-1 activates insulin receptors and increases glucose uptake.
What to do
Monitor blood glucose closely and give mecasermin with or shortly after a meal or snack. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Mecasermin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Mecasermin?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin (recombinant IGF-1) has insulin-like effects and can cause hypoglycemia, which may be worsened by antidiabetic drugs. The risk is higher if meals are missed.
How serious is the interaction between Ertugliflozin-sitagliptin and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and give mecasermin with or shortly after a meal or snack. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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