Drug interactions
Ertugliflozin-sitagliptin + Nateglinide
Severity: Moderate
Ertugliflozin-sitagliptin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining nateglinide, an insulin secretagogue, with ertugliflozin and sitagliptin may increase hypoglycemia risk. The effect is usually modest but relevant when meals are skipped.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects through enhanced insulin secretion and increased urinary glucose excretion.
What to do
Consider reducing the nateglinide dose and monitor blood glucose, advising patients to take it only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Nateglinide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining nateglinide, an insulin secretagogue, with ertugliflozin and sitagliptin may increase hypoglycemia risk. The effect is usually modest but relevant when meals are skipped.
How serious is the interaction between Ertugliflozin-sitagliptin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the nateglinide dose and monitor blood glucose, advising patients to take it only with meals.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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