Drug interactions
Ertugliflozin-sitagliptin + Nelfinavir
Severity: Moderate
Ertugliflozin-sitagliptin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir can cause insulin resistance and hyperglycemia, which may blunt the effect of antidiabetic drugs. Glucose control may deteriorate in diabetic patients.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor induced insulin resistance opposes the glucose-lowering action.
What to do
Monitor blood glucose after starting nelfinavir and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Nelfinavir?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir can cause insulin resistance and hyperglycemia, which may blunt the effect of antidiabetic drugs. Glucose control may deteriorate in diabetic patients.
How serious is the interaction between Ertugliflozin-sitagliptin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting nelfinavir and adjust antidiabetic therapy as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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