Drug interactions
Ertugliflozin-sitagliptin + Repaglinide
Severity: Moderate
Ertugliflozin-sitagliptin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining repaglinide, an insulin secretagogue, with ertugliflozin and sitagliptin may increase the risk of hypoglycemia. The risk is greater when meals are irregular.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects through enhanced insulin secretion and increased urinary glucose excretion.
What to do
Consider reducing the repaglinide dose and monitor blood glucose, advising patients to take it only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Repaglinide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining repaglinide, an insulin secretagogue, with ertugliflozin and sitagliptin may increase the risk of hypoglycemia. The risk is greater when meals are irregular.
How serious is the interaction between Ertugliflozin-sitagliptin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the repaglinide dose and monitor blood glucose, advising patients to take it only with meals.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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