Drug interactions
Erythromycin + Silodosin
Severity: Moderate
Erythromycin and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise silodosin concentrations, increasing the risk of orthostatic hypotension, dizziness and syncope. The effect is less than with strong inhibitors but still relevant in older patients.
What this interaction means in plain words
Erythromycin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Silodosin belongs to Genitourinary.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, reducing silodosin clearance.
What to do
Monitor blood pressure and counsel patients about postural dizziness. Consider an alternative antibiotic in frail or hypotension-prone patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Erythromycin with Silodosin?
MediHelp rates the interaction as moderate. Erythromycin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may raise silodosin concentrations, increasing the risk of orthostatic hypotension, dizziness and syncope. The effect is less than with strong inhibitors but still relevant in older patients.
How serious is the interaction between Erythromycin and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about postural dizziness. Consider an alternative antibiotic in frail or hypotension-prone patients.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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