Drug interactions
Erythromycin lactobionate + Fluvoxamine
Severity: Moderate
Erythromycin lactobionate and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin prolongs the QT interval and can cause torsades de pointes, and the risk is higher with IV dosing. Fluvoxamine may add to this effect and inhibits CYP3A4, which may raise erythromycin levels.
What this interaction means in plain words
Erythromycin lactobionate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by both drugs.
What to do
Obtain a baseline ECG and monitor QTc during IV therapy. Correct potassium and magnesium disturbances and consider an alternative antibiotic where risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Fluvoxamine?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin prolongs the QT interval and can cause torsades de pointes, and the risk is higher with IV dosing. Fluvoxamine may add to this effect and inhibits CYP3A4, which may raise erythromycin levels.
How serious is the interaction between Erythromycin lactobionate and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during IV therapy. Correct potassium and magnesium disturbances and consider an alternative antibiotic where risk is high.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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