Drug interactions
Erythromycin lactobionate + Granisetron
Severity: Major
Erythromycin lactobionate and Granisetron: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin reaches high concentrations and is particularly associated with QT prolongation and torsades de pointes. Granisetron adds further QT effect, increasing the risk of serious arrhythmia.
What this interaction means in plain words
Erythromycin lactobionate and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive pharmacodynamic QT prolongation; erythromycin also inhibits CYP3A4, which contributes to granisetron metabolism.
What to do
Use a non-macrolide antibiotic or a different antiemetic when possible. If co-use is needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Granisetron?
MediHelp rates the interaction as major. Erythromycin lactobionate and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin reaches high concentrations and is particularly associated with QT prolongation and torsades de pointes. Granisetron adds further QT effect, increasing the risk of serious arrhythmia.
How serious is the interaction between Erythromycin lactobionate and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-macrolide antibiotic or a different antiemetic when possible. If co-use is needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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