Drug interactions
Erythromycin lactobionate + Haloperidol
Severity: Major
Erythromycin lactobionate and Haloperidol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin prolongs the QT interval and inhibits CYP3A4, which contributes to haloperidol clearance. The combination raises the risk of torsades de pointes, particularly with rapid infusion.
What this interaction means in plain words
Erythromycin lactobionate and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation with erythromycin inhibition of CYP3A4 raising haloperidol concentrations.
What to do
Prefer a non-macrolide antibiotic without QT effects. If used together, give erythromycin slowly, monitor the ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Haloperidol?
MediHelp rates the interaction as major. Erythromycin lactobionate and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin prolongs the QT interval and inhibits CYP3A4, which contributes to haloperidol clearance. The combination raises the risk of torsades de pointes, particularly with rapid infusion.
How serious is the interaction between Erythromycin lactobionate and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-macrolide antibiotic without QT effects. If used together, give erythromycin slowly, monitor the ECG and correct potassium and magnesium.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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