Drug interactions
Erythromycin lactobionate + Indacaterol-glycopyrronium
Severity: Moderate
Erythromycin lactobionate and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and P-glycoprotein and can raise systemic indacaterol exposure modestly. Both drugs can also affect cardiac repolarisation, so beta-agonist adverse effects and QT prolongation may be more likely.
What this interaction means in plain words
Erythromycin lactobionate and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 and P-gp reduces indacaterol clearance, with possible additive QT effects.
What to do
No dose change is generally needed at the standard inhaled dose, but monitor heart rate, potassium and QTc during IV therapy, especially with other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and P-glycoprotein and can raise systemic indacaterol exposure modestly. Both drugs can also affect cardiac repolarisation, so beta-agonist adverse effects and QT prolongation may be more likely.
How serious is the interaction between Erythromycin lactobionate and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed at the standard inhaled dose, but monitor heart rate, potassium and QTc during IV therapy, especially with other QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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