Drug interactions
Erythromycin lactobionate + Lurasidone
Severity: Moderate
Erythromycin lactobionate and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin is a moderate CYP3A4 inhibitor and raises lurasidone exposure, increasing risk of dose-related adverse effects such as akathisia, sedation and parkinsonism.
What this interaction means in plain words
Erythromycin lactobionate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Lurasidone belongs to Central Nervous System.
Why it happens
Erythromycin inhibits CYP3A4 metabolism of lurasidone.
What to do
Start lurasidone at 20 mg daily and cap at 80 mg daily during co-administration. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Lurasidone?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin is a moderate CYP3A4 inhibitor and raises lurasidone exposure, increasing risk of dose-related adverse effects such as akathisia, sedation and parkinsonism.
How serious is the interaction between Erythromycin lactobionate and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lurasidone at 20 mg daily and cap at 80 mg daily during co-administration. Monitor for adverse effects.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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