Drug interactions
Erythromycin lactobionate + Paliperidone
Severity: Major
Erythromycin lactobionate and Paliperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin prolongs the QT interval, and paliperidone does too, so the combination raises the risk of torsades de pointes. Erythromycin also inhibits P-glycoprotein, which may modestly raise paliperidone exposure.
What this interaction means in plain words
Erythromycin lactobionate and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus P-glycoprotein inhibition that increases paliperidone absorption.
What to do
Use a non-QT-prolonging antibiotic where appropriate. If the combination is necessary, obtain an ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Paliperidone?
MediHelp rates the interaction as major. Erythromycin lactobionate and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin prolongs the QT interval, and paliperidone does too, so the combination raises the risk of torsades de pointes. Erythromycin also inhibits P-glycoprotein, which may modestly raise paliperidone exposure.
How serious is the interaction between Erythromycin lactobionate and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic where appropriate. If the combination is necessary, obtain an ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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