Drug interactions
Erythromycin lactobionate + Solifenacin
Severity: Major
Erythromycin lactobionate and Solifenacin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4, raising solifenacin exposure, and both drugs can prolong the QT interval. This raises the risk of torsades de pointes, particularly in hospitalized patients with electrolyte disturbances.
What this interaction means in plain words
Erythromycin lactobionate and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by erythromycin plus additive QT prolongation.
What to do
Use a non-macrolide antibiotic if possible, or hold solifenacin during treatment. If both are needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Solifenacin
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Solifenacin?
MediHelp rates the interaction as major. Erythromycin lactobionate and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin inhibits CYP3A4, raising solifenacin exposure, and both drugs can prolong the QT interval. This raises the risk of torsades de pointes, particularly in hospitalized patients with electrolyte disturbances.
How serious is the interaction between Erythromycin lactobionate and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-macrolide antibiotic if possible, or hold solifenacin during treatment. If both are needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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