Drug interactions
Eslicarbazepine + Idelalisib
Severity: Major
Eslicarbazepine and Idelalisib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib exposure falls substantially with strong CYP3A inducers. Eslicarbazepine is weaker but could still reduce concentrations and oncologic efficacy.
What this interaction means in plain words
Eslicarbazepine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
CYP3A4 induction by eslicarbazepine increases idelalisib clearance.
What to do
Use a non-inducing antiseizure drug where possible and monitor disease response if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eslicarbazepine Amarox 200 mg tablets - SmPC sections 4.3/4.5 (class statement: medicinal products that are mainly metabolised through CYP3A4; "an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with Eslicarbazepine… — electronic medicines compendium (UK SmPC)
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Eslicarbazepine with Idelalisib?
MediHelp rates the interaction as major. Eslicarbazepine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib exposure falls substantially with strong CYP3A inducers. Eslicarbazepine is weaker but could still reduce concentrations and oncologic efficacy.
How serious is the interaction between Eslicarbazepine and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiseizure drug where possible and monitor disease response if combined.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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