Drug interactions
Eslicarbazepine + Modafinil
Severity: Minor
Eslicarbazepine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and inhibits CYP2C19, so its effect on modafinil is unclear and likely small. Modafinil exposure could be reduced through induction, which is the more relevant theoretical effect.
What this interaction means in plain words
Eslicarbazepine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Eslicarbazepine has mixed weak CYP3A4 induction and CYP2C19 inhibition, with net effect on modafinil not established.
What to do
No routine adjustment is needed; monitor modafinil efficacy and tolerability after starting or stopping eslicarbazepine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Modafinil?
MediHelp rates the interaction as minor. Eslicarbazepine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine is a weak CYP3A4 inducer and inhibits CYP2C19, so its effect on modafinil is unclear and likely small. Modafinil exposure could be reduced through induction, which is the more relevant theoretical effect.
How serious is the interaction between Eslicarbazepine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor modafinil efficacy and tolerability after starting or stopping eslicarbazepine.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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