Drug interactions
Eslicarbazepine + Nevirapine
Severity: Moderate
Eslicarbazepine and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce nevirapine concentrations, which could compromise virologic suppression. Evidence is limited and mostly extrapolated from related antiepileptics such as carbamazepine.
What this interaction means in plain words
Eslicarbazepine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Eslicarbazepine induces CYP3A4, increasing nevirapine metabolism.
What to do
Monitor HIV viral load and consider nevirapine trough levels. Consider an antiepileptic with less induction potential if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Nevirapine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce nevirapine concentrations, which could compromise virologic suppression. Evidence is limited and mostly extrapolated from related antiepileptics such as carbamazepine.
How serious is the interaction between Eslicarbazepine and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider nevirapine trough levels. Consider an antiepileptic with less induction potential if feasible.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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