Drug interactions
Eslicarbazepine + Repotrectinib
Severity: Major
Eslicarbazepine and Repotrectinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is mainly cleared by CYP3A4, and strong or moderate CYP3A inducers markedly reduce its exposure. Eslicarbazepine has modest CYP3A4 induction, so lower repotrectinib levels and reduced anticancer activity are possible.
What this interaction means in plain words
Eslicarbazepine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Eslicarbazepine induces CYP3A4, increasing the metabolism of repotrectinib (the CYP2E1 route cited is not the established mechanism).
What to do
Choose a non-inducing antiseizure drug such as levetiracetam where feasible. If it must be combined, monitor tumor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eslicarbazepine Amarox 200 mg tablets - SmPC sections 4.3/4.5 (class statement: medicinal products that are mainly metabolised through CYP3A4; "an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with Eslicarbazepine… — electronic medicines compendium (UK SmPC)
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Eslicarbazepine with Repotrectinib?
MediHelp rates the interaction as major. Eslicarbazepine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is mainly cleared by CYP3A4, and strong or moderate CYP3A inducers markedly reduce its exposure. Eslicarbazepine has modest CYP3A4 induction, so lower repotrectinib levels and reduced anticancer activity are possible.
How serious is the interaction between Eslicarbazepine and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inducing antiseizure drug such as levetiracetam where feasible. If it must be combined, monitor tumor response closely.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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