Drug interactions
Eslicarbazepine + Tramadol
Severity: Moderate
Eslicarbazepine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and may reduce tramadol concentrations and efficacy. Both drugs can also affect seizure control, as tramadol lowers the seizure threshold in epilepsy.
What this interaction means in plain words
Eslicarbazepine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by eslicarbazepine increasing tramadol metabolism; tramadol lowers seizure threshold.
What to do
Monitor analgesic response and seizure control, and consider an alternative analgesic in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Tramadol?
MediHelp rates the interaction as moderate. Eslicarbazepine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak CYP3A4 inducer and may reduce tramadol concentrations and efficacy. Both drugs can also affect seizure control, as tramadol lowers the seizure threshold in epilepsy.
How serious is the interaction between Eslicarbazepine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and seizure control, and consider an alternative analgesic in patients with epilepsy.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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