Drug interactions
Eslicarbazepine + Trimipramine
Severity: Moderate
Eslicarbazepine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can inhibit CYP2C19, which contributes to trimipramine metabolism, so tricyclic concentrations may rise. Higher levels could increase sedation, anticholinergic effects and cardiac toxicity; tricyclics can also lower the seizure threshold.
What this interaction means in plain words
Eslicarbazepine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated metabolism of trimipramine.
What to do
Monitor for tricyclic adverse effects and consider checking drug levels or reducing the trimipramine dose. Watch seizure control in epilepsy patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Trimipramine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine can inhibit CYP2C19, which contributes to trimipramine metabolism, so tricyclic concentrations may rise. Higher levels could increase sedation, anticholinergic effects and cardiac toxicity; tricyclics can also lower the seizure threshold.
How serious is the interaction between Eslicarbazepine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider checking drug levels or reducing the trimipramine dose. Watch seizure control in epilepsy patients.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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