Drug interactions
Eslicarbazepine + Valbenazine
Severity: Moderate
Eslicarbazepine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine and its active metabolite are cleared partly via CYP3A4, and strong inducers markedly lower exposure. Eslicarbazepine is a weaker inducer but may reduce efficacy against tardive dyskinesia.
What this interaction means in plain words
Eslicarbazepine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, increasing valbenazine and active metabolite clearance.
What to do
Monitor tardive dyskinesia control and consider an alternative antiseizure drug if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Eslicarbazepine with Valbenazine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine and its active metabolite are cleared partly via CYP3A4, and strong inducers markedly lower exposure. Eslicarbazepine is a weaker inducer but may reduce efficacy against tardive dyskinesia.
How serious is the interaction between Eslicarbazepine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tardive dyskinesia control and consider an alternative antiseizure drug if response declines.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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