Drug interactions
Eslicarbazepine + Vortioxetine
Severity: Moderate
Eslicarbazepine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak-to-moderate enzyme inducer and may lower vortioxetine concentrations, potentially diminishing antidepressant efficacy. The effect is less than with strong inducers such as carbamazepine.
What this interaction means in plain words
Eslicarbazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Induction of hepatic CYP enzymes by eslicarbazepine accelerates vortioxetine metabolism and reduces exposure.
What to do
Monitor for loss of antidepressant response and consider increasing the vortioxetine dose within the labeled maximum if needed. Reduce the dose back if the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Vortioxetine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak-to-moderate enzyme inducer and may lower vortioxetine concentrations, potentially diminishing antidepressant efficacy. The effect is less than with strong inducers such as carbamazepine.
How serious is the interaction between Eslicarbazepine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and consider increasing the vortioxetine dose within the labeled maximum if needed. Reduce the dose back if the inducer is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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