Drug interactions
Eslicarbazepine + Zonisamide
Severity: Minor
Eslicarbazepine and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly cleared by CYP3A4, so eslicarbazepine may lower its concentrations, with possible loss of seizure control. The effect is probably modest.
What this interaction means in plain words
Eslicarbazepine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
CYP3A4 induction by eslicarbazepine may increase zonisamide clearance.
What to do
Monitor seizure control and consider zonisamide dose adjustment if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Eslicarbazepine with Zonisamide?
MediHelp rates the interaction as minor. Eslicarbazepine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly cleared by CYP3A4, so eslicarbazepine may lower its concentrations, with possible loss of seizure control. The effect is probably modest.
How serious is the interaction between Eslicarbazepine and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider zonisamide dose adjustment if breakthrough seizures occur.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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