Drug interactions
Esmolol + Indacaterol
Severity: Moderate
Esmolol and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers antagonize the bronchodilating action of indacaterol and may precipitate bronchospasm in patients with airway disease. Esmolol is short-acting and cardioselective, so the effect is typically transient and dose dependent.
What this interaction means in plain words
Esmolol and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, with reduced selectivity at higher esmolol doses.
What to do
Use esmolol at the lowest effective dose and monitor respiratory status and wheeze in patients with COPD or asthma. Have a short-acting bronchodilator available and stop esmolol if bronchospasm occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Indacaterol?
MediHelp rates the interaction as moderate. Esmolol and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers antagonize the bronchodilating action of indacaterol and may precipitate bronchospasm in patients with airway disease. Esmolol is short-acting and cardioselective, so the effect is typically transient and dose dependent.
How serious is the interaction between Esmolol and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use esmolol at the lowest effective dose and monitor respiratory status and wheeze in patients with COPD or asthma. Have a short-acting bronchodilator available and stop esmolol if bronchospasm occurs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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