Drug interactions
Esmolol + Insulin degludec-insulin aspart
Severity: Moderate
Esmolol and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol can mask the adrenergic warning symptoms of hypoglycemia and may delay glucose recovery. Because it is short acting and given by infusion, the effect is brief but relevant in monitored settings.
What this interaction means in plain words
Esmolol and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Beta-1 selective adrenergic blockade blunts counter-regulatory responses and hypoglycemia awareness.
What to do
Monitor blood glucose closely during esmolol infusion, particularly in sedated patients who cannot report symptoms. Adjust insulin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Esmolol and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol can mask the adrenergic warning symptoms of hypoglycemia and may delay glucose recovery. Because it is short acting and given by infusion, the effect is brief but relevant in monitored settings.
How serious is the interaction between Esmolol and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during esmolol infusion, particularly in sedated patients who cannot report symptoms. Adjust insulin as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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