Drug interactions
Esmolol + Metolazone
Severity: Minor
Esmolol and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and metolazone can have additive blood pressure lowering. Metolazone-related hypokalemia is relevant to arrhythmia risk in acutely ill patients, and beta-blockade may mask hypoglycemia.
What this interaction means in plain words
Esmolol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; thiazide-induced electrolyte and glucose changes may be relevant.
What to do
Monitor blood pressure, heart rate and serum potassium during esmolol infusion in patients receiving metolazone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Metolazone?
MediHelp rates the interaction as minor. Esmolol and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esmolol and metolazone can have additive blood pressure lowering. Metolazone-related hypokalemia is relevant to arrhythmia risk in acutely ill patients, and beta-blockade may mask hypoglycemia.
How serious is the interaction between Esmolol and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium during esmolol infusion in patients receiving metolazone.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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