Drug interactions
Esmolol + Sevoflurane
Severity: Moderate
Esmolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane causes dose-dependent vasodilation and myocardial depression, and esmolol adds negative chronotropic and inotropic effects. Hypotension and bradycardia can result during anesthesia.
What this interaction means in plain words
Esmolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression from volatile anesthetic vasodilation and beta-1 blockade.
What to do
Titrate esmolol carefully with continuous hemodynamic monitoring and adjust anesthetic depth as needed. Treat hypotension or bradycardia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Esmolol with Sevoflurane?
MediHelp rates the interaction as moderate. Esmolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane causes dose-dependent vasodilation and myocardial depression, and esmolol adds negative chronotropic and inotropic effects. Hypotension and bradycardia can result during anesthesia.
How serious is the interaction between Esmolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate esmolol carefully with continuous hemodynamic monitoring and adjust anesthetic depth as needed. Treat hypotension or bradycardia promptly.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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