Drug interactions
Esomeprazole + Fluvoxamine
Severity: Minor
Esomeprazole and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine strongly inhibits CYP2C19, the main enzyme that clears esomeprazole, so esomeprazole levels may rise. This is rarely harmful at standard doses, but exposure increases with long-term or high-dose use.
What this interaction means in plain words
Esomeprazole and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP2C19-mediated metabolism of esomeprazole.
What to do
No routine dose change is needed at standard doses. Reassess the esomeprazole dose if high doses are used long term or if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Esomeprazole with Fluvoxamine?
MediHelp rates the interaction as minor. Esomeprazole and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine strongly inhibits CYP2C19, the main enzyme that clears esomeprazole, so esomeprazole levels may rise. This is rarely harmful at standard doses, but exposure increases with long-term or high-dose use.
How serious is the interaction between Esomeprazole and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed at standard doses. Reassess the esomeprazole dose if high doses are used long term or if adverse effects appear.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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