Drug interactions
Esomeprazole + Iloperidone
Severity: Minor
Esomeprazole and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may weakly inhibit CYP3A4 and could raise esomeprazole levels. The effect is expected to be small and esomeprazole has a broad safety margin.
What this interaction means in plain words
Esomeprazole and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Iloperidone belongs to Central Nervous System.
Why it happens
Time-dependent inhibition of CYP3A4 slightly reduces esomeprazole clearance.
What to do
No routine adjustment is needed; monitor for esomeprazole adverse effects during long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Esomeprazole with Iloperidone?
MediHelp rates the interaction as minor. Esomeprazole and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone may weakly inhibit CYP3A4 and could raise esomeprazole levels. The effect is expected to be small and esomeprazole has a broad safety margin.
How serious is the interaction between Esomeprazole and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for esomeprazole adverse effects during long-term use.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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