Drug interactions
Esomeprazole + Nisoldipine
Severity: Minor
Esomeprazole and Nisoldipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raised gastric pH may change nisoldipine absorption, but the clinical significance is uncertain. The reported effect is a possible rise in levels with additive blood pressure lowering.
What this interaction means in plain words
Esomeprazole and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Nisoldipine belongs to Cardiovascular.
Why it happens
Altered gastric pH may change nisoldipine absorption, but the mechanism is not well established.
What to do
No empirical change is needed. Monitor blood pressure and watch for hypotension or edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Esomeprazole with Nisoldipine?
MediHelp rates the interaction as minor. Esomeprazole and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raised gastric pH may change nisoldipine absorption, but the clinical significance is uncertain. The reported effect is a possible rise in levels with additive blood pressure lowering.
How serious is the interaction between Esomeprazole and Nisoldipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed. Monitor blood pressure and watch for hypotension or edema.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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