Drug interactions
Esomeprazole + Ribociclib
Severity: Minor
Esomeprazole and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor, and CYP3A4 is a minor route of esomeprazole clearance, so esomeprazole exposure may rise slightly. This is unlikely to matter given the wide safety margin of the PPI.
What this interaction means in plain words
Esomeprazole and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, a secondary pathway for esomeprazole metabolism.
What to do
No dose adjustment is needed for esomeprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Esomeprazole with Ribociclib?
MediHelp rates the interaction as minor. Esomeprazole and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a CYP3A4 inhibitor, and CYP3A4 is a minor route of esomeprazole clearance, so esomeprazole exposure may rise slightly. This is unlikely to matter given the wide safety margin of the PPI.
How serious is the interaction between Esomeprazole and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for esomeprazole.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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