Drug interactions
Esomeprazole + Voriconazole
Severity: Moderate
Esomeprazole and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C19 and CYP3A4, the main enzymes clearing esomeprazole, and raises esomeprazole exposure. Voriconazole levels may also increase slightly. The increase in PPI exposure is usually well tolerated at standard doses.
What this interaction means in plain words
Esomeprazole and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19 and CYP3A4 metabolism of esomeprazole.
What to do
Consider reducing esomeprazole dose if high doses are used long term, such as in Zollinger-Ellison or erosive esophagitis. Monitor for PPI adverse effects and voriconazole toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esomeprazole and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Esomeprazole with Voriconazole?
MediHelp rates the interaction as moderate. Esomeprazole and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C19 and CYP3A4, the main enzymes clearing esomeprazole, and raises esomeprazole exposure. Voriconazole levels may also increase slightly. The increase in PPI exposure is usually well tolerated at standard doses.
How serious is the interaction between Esomeprazole and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing esomeprazole dose if high doses are used long term, such as in Zollinger-Ellison or erosive esophagitis. Monitor for PPI adverse effects and voriconazole toxicity.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
