Drug interactions
Estradiol + Etravirine
Severity: Moderate
Estradiol and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower estradiol concentrations, potentially reducing efficacy. Labeling notes that etravirine can alter ethinylestradiol exposure, so unpredictable hormonal effects are possible.
What this interaction means in plain words
Estradiol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by etravirine, increasing estradiol clearance.
What to do
Monitor for reduced estrogen effect and titrate the estradiol dose to response. If used for contraception, add a non-hormonal method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Estradiol with Etravirine?
MediHelp rates the interaction as moderate. Estradiol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower estradiol concentrations, potentially reducing efficacy. Labeling notes that etravirine can alter ethinylestradiol exposure, so unpredictable hormonal effects are possible.
How serious is the interaction between Estradiol and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced estrogen effect and titrate the estradiol dose to response. If used for contraception, add a non-hormonal method.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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