Drug interactions
Estradiol + Fosaprepitant
Severity: Minor
Estradiol and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor early on and later a weak inducer. After a single-dose course, any effect on estradiol is expected to be small and short-lived. Labeling for aprepitant notes that hormonal contraceptive efficacy may be reduced.
What this interaction means in plain words
Estradiol and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Transient CYP3A4 inhibition followed by weak induction by aprepitant.
What to do
No estradiol dose change is needed for menopausal use. If estradiol is relied on for contraception, use a backup method during and for about a month after treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Estradiol with Fosaprepitant?
MediHelp rates the interaction as minor. Estradiol and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor early on and later a weak inducer. After a single-dose course, any effect on estradiol is expected to be small and short-lived. Labeling for aprepitant notes that hormonal contraceptive efficacy may be reduced.
How serious is the interaction between Estradiol and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No estradiol dose change is needed for menopausal use. If estradiol is relied on for contraception, use a backup method during and for about a month after treatment.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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