Drug interactions
Estradiol + Gemifloxacin
Severity: Minor
Estradiol and Gemifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorized to lower estrogen levels by disrupting enterohepatic recirculation, but evidence for clinically meaningful loss of effect is weak. Non-rifamycin antibiotics are not generally considered to compromise hormonal contraception.
What this interaction means in plain words
Estradiol and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Theoretical reduction of gut bacterial deconjugation of estrogen conjugates, lowering enterohepatic recycling.
What to do
No routine action is needed. Advise patients on oral contraception to report breakthrough bleeding or vomiting and diarrhea that might reduce absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Gemifloxacin?
MediHelp rates the interaction as minor. Estradiol and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorized to lower estrogen levels by disrupting enterohepatic recirculation, but evidence for clinically meaningful loss of effect is weak. Non-rifamycin antibiotics are not generally considered to compromise hormonal contraception.
How serious is the interaction between Estradiol and Gemifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise patients on oral contraception to report breakthrough bleeding or vomiting and diarrhea that might reduce absorption.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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