Drug interactions
Estradiol + Iloperidone
Severity: Minor
Estradiol and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A4 inhibitor and could modestly increase estradiol exposure. Any clinical effect is expected to be small.
What this interaction means in plain words
Estradiol and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 reduces estradiol metabolism.
What to do
No dose adjustment is usually required; monitor for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Estradiol with Iloperidone?
MediHelp rates the interaction as minor. Estradiol and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak CYP3A4 inhibitor and could modestly increase estradiol exposure. Any clinical effect is expected to be small.
How serious is the interaction between Estradiol and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for estrogenic adverse effects.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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