Drug interactions
Estradiol + Itraconazole
Severity: Minor
Estradiol and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase systemic estradiol exposure. This can intensify estrogenic effects such as breast tenderness, fluid retention or breakthrough bleeding.
What this interaction means in plain words
Estradiol and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated estradiol metabolism and may inhibit P-glycoprotein efflux.
What to do
No routine dose change is needed; monitor for estrogen excess symptoms during prolonged itraconazole courses and reduce the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Itraconazole?
MediHelp rates the interaction as minor. Estradiol and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may increase systemic estradiol exposure. This can intensify estrogenic effects such as breast tenderness, fluid retention or breakthrough bleeding.
How serious is the interaction between Estradiol and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for estrogen excess symptoms during prolonged itraconazole courses and reduce the estradiol dose if they occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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