Drug interactions
Estradiol + Moxifloxacin
Severity: Minor
Estradiol and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to reduce oral estrogen exposure by disrupting gut bacteria involved in enterohepatic recycling. Pharmacokinetic studies have generally not shown a meaningful effect, and clinical impact is unlikely.
What this interaction means in plain words
Estradiol and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogens through altered gut flora; not established for moxifloxacin.
What to do
No routine change is needed. Advise patients on hormonal contraception to report breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Moxifloxacin?
MediHelp rates the interaction as minor. Estradiol and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to reduce oral estrogen exposure by disrupting gut bacteria involved in enterohepatic recycling. Pharmacokinetic studies have generally not shown a meaningful effect, and clinical impact is unlikely.
How serious is the interaction between Estradiol and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients on hormonal contraception to report breakthrough bleeding.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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