Drug interactions
Estradiol + Nitrofurantoin
Severity: Minor
Estradiol and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
It has been proposed that antibiotics disrupt gut flora and reduce enterohepatic recycling of estrogens. Controlled data show no meaningful loss of efficacy for most non-rifamycin antibiotics, so clinical significance is very low.
What this interaction means in plain words
Estradiol and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through alteration of intestinal flora.
What to do
No change to hormonal therapy is normally required. Advise the patient to report breakthrough bleeding or vomiting and diarrhoea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Nitrofurantoin?
MediHelp rates the interaction as minor. Estradiol and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. It has been proposed that antibiotics disrupt gut flora and reduce enterohepatic recycling of estrogens. Controlled data show no meaningful loss of efficacy for most non-rifamycin antibiotics, so clinical significance is very low.
How serious is the interaction between Estradiol and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change to hormonal therapy is normally required. Advise the patient to report breakthrough bleeding or vomiting and diarrhoea.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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