Drug interactions
Estradiol + Tacrolimus
Severity: Minor
Estradiol and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can inhibit P-glycoprotein and could marginally raise estradiol levels. Estrogens may also modestly increase tacrolimus exposure, but clinical significance is generally small.
What this interaction means in plain words
Estradiol and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible P-glycoprotein inhibition by tacrolimus; not well established for estradiol.
What to do
No change is needed; check tacrolimus trough levels if estrogen therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Estradiol with Tacrolimus?
MediHelp rates the interaction as minor. Estradiol and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus can inhibit P-glycoprotein and could marginally raise estradiol levels. Estrogens may also modestly increase tacrolimus exposure, but clinical significance is generally small.
How serious is the interaction between Estradiol and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed; check tacrolimus trough levels if estrogen therapy is started or stopped.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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