Drug interactions
Estradiol + Tipranavir
Severity: Major
Estradiol and Tipranavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir lowers circulating ethinylestradiol, so hormonal contraception may fail. Unintended pregnancy is a concern, and hormone-related adverse effects have also been reported.
What this interaction means in plain words
Estradiol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Estradiol belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir induces estrogen metabolism, including glucuronidation and CYP enzymes.
What to do
Use an alternative or additional non-hormonal contraception. For hormone replacement, monitor for loss of symptom control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Tipranavir?
MediHelp rates the interaction as major. Estradiol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir boosted with ritonavir lowers circulating ethinylestradiol, so hormonal contraception may fail. Unintended pregnancy is a concern, and hormone-related adverse effects have also been reported.
How serious is the interaction between Estradiol and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative or additional non-hormonal contraception. For hormone replacement, monitor for loss of symptom control.
What other medicines interact with Tipranavir?
MediHelp also lists interactions of Tipranavir with, for example, Alfuzosin, Amiodarone, Atorvastatin. The full list is on the Tipranavir page.
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