Drug interactions
Eszopiclone + Metoclopramide
Severity: Moderate
Eszopiclone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, dizziness and impaired alertness. Used together, next-day drowsiness and psychomotor impairment may be increased.
What this interaction means in plain words
Eszopiclone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Counsel on additive sedation and avoid driving or hazardous tasks. Consider using the lowest eszopiclone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Metoclopramide?
MediHelp rates the interaction as moderate. Eszopiclone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, dizziness and impaired alertness. Used together, next-day drowsiness and psychomotor impairment may be increased.
How serious is the interaction between Eszopiclone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving or hazardous tasks. Consider using the lowest eszopiclone dose.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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