Drug interactions
Ethacrynic acid + Hydrochlorothiazide-irbesartan
Severity: Moderate
Ethacrynic acid and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces sequential nephron blockade, with a strong diuresis and a high risk of hypokalemia, hyponatremia, hypovolemia and renal impairment. Combined with an ARB, hypotension and renal dysfunction are more likely.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive inhibition of sodium reabsorption in the loop of Henle and distal tubule increases urinary sodium, water and potassium loss.
What to do
Monitor electrolytes, renal function, weight and blood pressure closely, and adjust diuretic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide produces sequential nephron blockade, with a strong diuresis and a high risk of hypokalemia, hyponatremia, hypovolemia and renal impairment. Combined with an ARB, hypotension and renal dysfunction are more likely.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, and adjust diuretic doses accordingly.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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