Drug interactions
Ethacrynic acid + Hydrochlorothiazide
Severity: Moderate
Ethacrynic acid and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces sequential nephron blockade with a markedly enhanced diuresis. This can cause profound loss of potassium, sodium, magnesium and volume, leading to hypokalemia, hyponatremia and hypotension.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Blockade of sodium reabsorption at both the loop of Henle and distal tubule produces additive natriuresis and potassium wasting.
What to do
Monitor electrolytes, renal function, weight and blood pressure closely, particularly in the first days of combined therapy, and replace potassium and magnesium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide produces sequential nephron blockade with a markedly enhanced diuresis. This can cause profound loss of potassium, sodium, magnesium and volume, leading to hypokalemia, hyponatremia and hypotension.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, particularly in the first days of combined therapy, and replace potassium and magnesium as required.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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