Drug interactions
Ethacrynic acid + Indacaterol
Severity: Moderate
Ethacrynic acid and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause potassium loss, and beta-agonists can shift potassium into cells. Together they may cause clinically relevant hypokalemia, which can predispose to arrhythmias.
What this interaction means in plain words
Ethacrynic acid and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from diuretic-induced renal potassium wasting and beta-2 agonist-driven intracellular potassium shift.
What to do
Check serum potassium at baseline and periodically, and replace potassium or magnesium as needed. Be more vigilant in patients with heart disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Indacaterol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause potassium loss, and beta-agonists can shift potassium into cells. Together they may cause clinically relevant hypokalemia, which can predispose to arrhythmias.
How serious is the interaction between Ethacrynic acid and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, and replace potassium or magnesium as needed. Be more vigilant in patients with heart disease or on other QT-prolonging drugs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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