Drug interactions
Ethacrynic acid + Sotalol
Severity: Major
Ethacrynic acid and Sotalol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics cause potassium and magnesium loss, which increases the risk of QT prolongation and torsade de pointes with sotalol.
What this interaction means in plain words
Ethacrynic acid and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Diuretic-induced electrolyte depletion potentiates sotalol's QT-prolonging effect.
What to do
Monitor potassium and magnesium, replace deficits, and monitor the QTc interval.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Sotalol?
MediHelp rates the interaction as major. Ethacrynic acid and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics cause potassium and magnesium loss, which increases the risk of QT prolongation and torsade de pointes with sotalol.
How serious is the interaction between Ethacrynic acid and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium, replace deficits, and monitor the QTc interval.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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