Drug interactions
Ethacrynic acid + Tiotropium-olodaterol
Severity: Moderate
Ethacrynic acid and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that causes potassium loss, and olodaterol can lower serum potassium by shifting it into cells. Combined hypokalemia may predispose to cardiac arrhythmias, particularly in patients with heart disease.
What this interaction means in plain words
Ethacrynic acid and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium periodically and replace as needed. Take extra care in patients on digoxin or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that causes potassium loss, and olodaterol can lower serum potassium by shifting it into cells. Combined hypokalemia may predispose to cardiac arrhythmias, particularly in patients with heart disease.
How serious is the interaction between Ethacrynic acid and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace as needed. Take extra care in patients on digoxin or other QT-prolonging drugs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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